Lists of research on gulf war illness and some research that veterans can get into.
We feel it is best if veterans get into as many research projects as they can. This is how we will be able to solve the mystery.
Study Links Deployment to Hypertension
DoD medical researchers have found that service members who suffered multiple combat exposures during a deployment, and especially those who had witnessed death as a result of war, were much more likely to report hypertension (chronic high blood pressure) compared to those who had not seen combat.
The study, a large population-based cohort conducted by researchers from the Millennium Cohort Study Team based out of the Department of Defense Center for Deployment Health Research at the Naval Health Research Center in San Diego, showed that 6.9 percent of service members surveyed were reporting hypertension within a three-year period. Out of that number, service members who deployed and reported multiple combat exposures were at significantly increased risk for reporting new cases of hypertension.
Mediated Airway Sensitivity as a Mechanism for Respiratory Symptoms
Epithelial Cell TRPV1-Mediated Airway Sensitivity as a Mechanism for Respiratory Symptoms Associated with Gulf War Illness
Principal Investigator:ZURAW, BRUCE Institution Receiving Award:VETERANS MEDICAL RESEARCH FOUNDATION OF SAN DIEGO Program:GWIRP Proposal Number:GW080156 Funding Mechanism:Investigator-Initiated Research Award Partnering Awards: Award Amount:$842,400.00
Veterans deployed to the Persian Gulf during the 1991 Gulf War have an unexplained high prevalence of multisymptom health problems compared to non-veterans or veterans not deployed to the Persian Gulf. Despite 17 years passing since the end of the war, veterans with Gulf War Illness continue to suffer from these symptoms. Frustratingly, neither the cause of Gulf War Illness nor the mechanisms responsible for continuing symptoms have been determined. The failure to understand the underlying mechanisms of this illness strongly contribute to the failure to develop effective therapy.
Principal Investigator:CONBOY, LISA Institution Receiving Award:NEW ENGLAND SCHOOL OF ACUPUNCTURE, INC. Program:GWIRP Proposal Number:GW080059 Funding Mechanism:Clinical Trial Award Partnering Awards:
PUBLIC ABSTRACT
Gulf War Illness (GWI) is a complex, poorly understood illness characterized by many symptoms, including fatigue after exertion, sleep and mood problems, difficulty concentrating, difficulty thinking and finding words, and musculoskeletal pain. Individuals often present with many symptoms, some of them severe and disabling, and with additional medical diagnoses, including chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, digestive complaints, and mood-related psychiatric disorders, such as depression, post-traumatic stress disorder, and other anxiety disorders. More than 100,000 veterans of the first Gulf War (Operation Desert Shield/Storm, 1990-1991) out of 700,000 U.S. service personnel deployed to the Persian Gulf have presented with medical complaints through programs established to address the problem, which came to be called chronic multisymptom illness (CMI). Groups of veterans in the United Kingdom, Canada, and Australia were identified with similar problems. The veterans have received treatment directed at their symptoms, but at 5- and 10-year follow-ups, many reported their symptoms remained, some of them severe and disabling. Clearly, an effective treatment for these conditions would be of great benefit to those who were injured during their military service.
Trial of Naltrexone and Dextromethorphan for Gulf War Veterans' Illness
Principal Investigator:MEGGS, WILLIAM J Institution Receiving Award:EAST CAROLINA UNIVERSITY Program:GWIRP Proposal Number:GW080064 Funding Mechanism:Clinical Trial Award Partnering Awards: Award Amount:$1,063,641.00
PUBLIC ABSTRACT
Armed services personnel in the 1991 Gulf War were exposed to a complex mixture of chemicals, including organophosphate insecticides, smoke from oil well fires, fuel oil, sarin gas, DEET, pyrethrums, and pyridostigmine bromide. Approximately 15% became chronically ill with a variety of symptoms that did not add up to a known disease. Nervous system symptoms such as difficulties with memory, thinking, and mood are commonly reported. Conventional medical practice has little to offer the ill veterans of the Gulf War. Pharmaceuticals have demonstrated neuroprotective effects in animal models and might provide symptomatic relief to ill Gulf War veterans, and these include naltrexone and dextromethorphan. Naltrexone is a chemical in this class that is a readily available generic drug with few side effects. Naltrexone is used to reverse effects of heroin and other opioid drugs. This study will determine in a scientific fashion if naltrexone and dextromethorphan are effective in treating ill Gulf War veterans
Exercise-Induced Cerebrospinal Fluid Proteomic Biomarkers of Fatigue
Principal Investigator:BARANIUK, JAMES N Institution Receiving Award:GEORGETOWN UNIVERSITY Program:GWIRP Proposal Number:GW080053 Funding Mechanism:Investigator-Initiated Research Award Partnering Awards: Award Amount:$921,000.00
The objective of this study is to understand what goes wrong in Gulf War Illness (GWI). We have previously performed lumbar punctures (spinal taps) in GWI subjects and identified a dozen proteins that were present in GWI but not "healthy control" subjects. This suggested that these proteins may be useful as biomarkers of GWI, and that they may be used to develop new tests for the condition. The pattern of the proteins also provided some ideas about how the brain may be injured in GWI. Long lasting, low-grade injury could lead to the symptoms of GWI and related illnesses such as chronic fatigue syndrome and fibromyalgia.
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